As per the report published by Fior Markets, the global histone deacetylase (HDAC) inhibitors market is expected to grow from USD 97.54 million in 2018 to USD 162.76 million by 2026 at a CAGR of 7.11% during the forecast period 2019-2026.Early adoption of innovative therapeutics, presence of sophisticated healthcare infrastructure, high R&D spending capacity, and rapid technological advancements are the factors that led to the growth of histone deacetylase (HDAC) inhibitors market in North America region.


Histone Deacetylase (HDAC) Inhibitors Market by Application (Oncology, Neurology, Others), End User (Hospitals, Oncology Clinics, Others), Region and Global Forecast 2019-2026.

Prominent companies in the industry include Merck & Co., Inc., Celgene Corporation, Eisai Pharmaceuticals, Novartis AG, Acetylon Pharmaceuticals, Celleron Therapeutics, Envivo Pharmaceuticals, Pfizer, Inc, Shenzhen Chipscreen Biosciences Co., Ltd., Spectrum Pharmaceuticals, Inc., Acetylon Pharmaceuticals, Celleron Therapeutics, Evgen Pharma, Johnson and Johnson, NuPotential, Syndax Pharmaceuticals, Sigma Tau Pharmaceuticals, Oncolys Biopharma, Chipscreen Biosciences, Bayer Schering Pharma, and others.The Celgene Corporation, Merck & Co., Inc., Novartis AG, Shenzhen Chipscreen Biosciences Co., Ltd., and Spectrum Pharmaceuticals, Inc are the top leading players of the market.In order to their enhance market position, the key players are now focusing on adopting the strategies such as product innovations, mergers & acquisitions, recent developments, joint venture, collaborations, and partnership. For instance, in 2015, Merck signed an agreement to test Keytruda (pembrolizumab) alongside Syndax’s histone deacetylase (HDAC) inhibitor entinostat in phase 1b/2 trials in melanoma and non-small cell lung cancer (NSCLC), with a view to progressing quickly to full-blown phase 3 studies.

The histone deacetylase (HDAC) inhibitors market is segmented on the basis of application and end user.Application segment includes oncology, neurology, and others. The oncology segment held the highest market size of around USD 85.48million in 2018 owing to huge patient base and increasing need for novel therapies for the treatment of cancer patients.Histone Deacetylase (HDAC) inhibitors increases the acetylation of lysine residues on histone proteins by inhibiting the activity of HDAC enzymes. Histone deacetylase (HDAC) inhibitors are important epigenetic mechanisms that regulate gene expression and transcription. The increasing need for innovative medications and improved therapies are used to targets for cancer immunotherapy.Histone Deacetylase (HDAC) inhibitors are anti-cancer compounds that helps the body’s own immune cells to recognize and attack tumour cells.End user segment is divided into hospitals, oncology clinics, and others. The oncology clinics segment registered the highest market share of 48.16% in 2018 and is anticipated to dominate the market in the forecast period owing to growing adoption of novel therapies for cancer treatment and increasing frequency of cancer worldwide. Histone deacetylase (HDAC) inhibitors are used in psychiatry and neurology as mood stabilizers and anti-epileptics.The increasing prevalence of cancers such as bowel cancer is increasing because of the high consumption of diets rich in red meat and processed meats. This has increased demand for histone deacetylase (HDAC) inhibitors that inhibit the actions of HDAC enzyme. The presence of a strong pipeline of oral HDAC inhibitors and the availability of financial assistance through patient assistance programs has driven the segment growth of oncology clinics segment.


Histone Deacetylase (HDAC) inhibitors induce cancer cell cycle arrest, differentiation and cell death. However, the drugs used for this therapy have a narrow therapeutic index, and the produced responsesare often only palliative as well as unpredictable. Histone Deacetylase (HDAC) inhibitors induce cancer cell cycle arrest, differentiation and celldeath, reduce angiogenesis and modulate immune response. Increase in cancer incidences, high unmet need in the treatment landscape, and demand for histone deacetylase inhibitorsare the key driving factors for the histone deacetylase (HDAC) inhibitors market.The reimbursement, uncertainty issues and stringent reimbursement policies may limit the growth of market. However, increasing R&D activities for cancer and increase in collaborations and huge investments in manufacturing is expected to boost the histone deacetylase (HDAC) inhibitors market over the forecast period.

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