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Acne patients are at a higher risk of depression, according to a new study published in the British Journal of Dermatology. They have a significantly increased risk of developing major depression.

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We already know that acne can be painful, frustrating, and it’s difficult to find a solution for the condition, so the new study showed that those suffering from the skin condition are more likely to develop depression.

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A new study, led by researchers at the University of Calgary in Canada monitored acne patients’ mood symptoms. The study used information from a major primary care database in the UK, gathered between 1986 and 2012 to discover the link between the skin disease and depression.

The study followed 134,427 patients with acne and 1,731,608 without, and the majority were aged under 19 at the starting of the study.

The research results found that the probability of developing depression was 18.5% for acne patients and 12 % for those without acne. The risk of depression among the patients was high in the first year of diagnosis. The risk was 63 percent higher compared to individuals without acne, the study says. the researchers concluded that acne patients are at a higher risk of depression.

Lead author Dr. Isabelle Vallerand of the University of Calgary said, “This study highlights an important link between skin disease and the mental illness. Given the risk of depression was highest in the period right after the first time a patient presented to a physician for acne concerns, it shows just how impactful our skin can be towards our overall mental health.”